Darzalex Injection Multiple Myeloma Treatment – healthandconditons
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Darzalex Injection Multiple Myeloma Treatment

Developed by Janssen Biotech and Genmab, Darzalex™ or daratumumab became the first FDA-approved monoclonal antibody for the treatment of patients with multiple myeloma.

Darzalex Uses

Approved for the treatment of individuals with multiple myeloma, Darzalex is available as injections, taken intravenously at a 16-mg per kg.

Daratumumab may sometimes be prescribed in conjunction with drugs known as lenalidomide or bortezomib (biologic drugs) and dexamethasone. The medication is approved to be used by those who have previously had a different treatment protocol for their disease.

Daratumumab may also be prescribed on its own to those who have been on a minimum of three separate medications for the treatment of multiple myeloma such as a proteasome inhibitor and an immunotherapy drug, but it can also be used by those whose myeloma did not respond to a proteasome inhibitor or an immunotherapy drug.

How Darzalex/Daratumumab Works

Darzalex attaches itself to CD38, a glycoprotein located on the outside of myeloma cells. It works by hindering the growth of myeloma cells in numerous ways, as well as by directly prompting immune cells to destroy myeloma cells.

Who Should Use Darzalex?

Clinical studies for Darzalex/daratumumab have included patients with both relapsed myeloma as well as refractory myeloma, and the medication was effective in the following groups of individuals:

– Individuals who have had prior treatment

– Individuals who did not respond to proteasome inhibitors or immunotherapy drugs

– Individuals who have undergone high-dose chemotherapy or a stem-cell transplant

– Those with impaired kidney capacity

– Those with moderately impaired liver function

Are there any side effects?

Based on data from the clinical studies, the most commonly reported side effects of Darzalex (daratumumab) are reactions at injection sites, nausea, fatigue, fever, back aches, and coughing. Darzalex may also result in a decrease in lymphocyte, red blood cell, and platelet counts.

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